Q. What is EvexiPEL?

A. EvexiPEL is the flagship therapy of EVEXIAS Health Solutions. This method delivers

life-changing bioidentical hormone therapy. EVEXIAS achieves this exclusively through

strategic partnership with a leading compounding pharmacy and FDA-registered 503B

outsourcing facility. This comprehensive approach combines physiological principles with

innovative techniques to optimize hormone levels in both women and men.

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Q. How do I know if I’m a candidate for pellets?

A. If you experience a combination of fatigue, depressed mood, and lower/absent libido,

you may have Androgen Insufficiency Syndrome (AIS). Hormone Replacement Therapy (HRT)

is a highly effective treatment for AIS. Additionally, if you prefer a minimally invasive

procedure every 3-4 months (4-6 months for men), you are an ideal candidate.

Other symptoms that often improve with bio-identical hormone optimization include insomnia,

early waking, anxiety, lack of energy/drive, lethargy, joint pain, and daytime sleepiness.

To confirm a suspected diagnosis of AIS and begin your evaluation, your physician will order

lab work to assess your hormone levels. These results will be discussed during your initial

consultation.

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Q. Do I have blood work done before each treatment?

A. Initial bloodwork is performed to establish baseline hormone levels, aid in diagnosing

AIS, and assess any imbalances in other major hormone systems (e.g., adrenal, thyroid). These

values will help determine your initial dosage.

Four weeks after your first pellet insertion, you will have repeat labs (a smaller panel). These

results will be reviewed at your six-week follow-up visit.

Thereafter, a full panel of labs is drawn annually. If you experience any significant changes in

symptoms related to hormone therapy, your nurse practitioner will recommend reassessment at

that time.

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Q. What are the pellets made from?

A. The EvexiPEL method features the patented - pellet that is plant based and derived from yams

and designed to be an exact replication of what the body produces in contrast to synthetic 

hormones. This pellet is specifically designed to improve patient comfort and deliver sustained,

steady dosing throughout the treatment cycle.

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Q. How long will the treatment last?

A. For women, the effects typically last an average of 3-4 months. Very active individuals may

require therapy every 3 months or sooner, while less active or elderly individuals may experience

benefits for longer than 4 months. In men, the typical cycle ranges from 4-6 months. The return

of early symptoms of hormone insufficiency, such as fatigue, joint pain, or decreased libido, can

indicate the need for your next insertion.

Q. Is the therapy FDA approved?

A. The individual ingredients within the pellets are FDA-approved, and the distribution of these

pellets is regulated by the FDA. However, the pellet insertion procedure itself is not FDA-

approved. It's common for physicians to prescribe medications or therapies for uses not explicitly

approved by the FDA (off-label) if they believe them to be safe and effective for their patients.

The reason bio-identical hormones (compounded drugs) are not FDA-approved is due to their

individualized dosing nature.

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Q. How are they administered?

A. Pellets are inserted using a very minor surgical procedure, performed in the office setting and

requiring only local anesthesia. Using a very small incision (~ 1-2 cm in women, ~ 3-4 cm in

men), they are inserted subcutaneously below the belt and above the buttock in women, and in

the posterior flank in men. Recovery is very quick and uncomplicated; exercise restrictions for 3

days in women and 5 days in men are simply to avoid complications.

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Q. Does it matter if I’m on birth control?

A. Not at all. Certain types may have an influence on therapy, which your physician/provider

will review with you.

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Q. Are there any side effects?

A. There are no serious or permanent side effects. In some cases, nuisance side effects can occur,

such as hair growth or acne, both of which are very treatable.

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Q. What if I’m already on some form of HRT, like creams, patches, or pills?

A. Transitioning to pellet therapy from other forms of HRT is common. Your physician can

assess your needs even if you're currently using another type of hormone replacement therapy. If

you prefer to continue with your current HRT but are not ready for pellets, we can offer

alternative formulations.

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Q. What if I’ve had breast cancer?

A.There is no direct causative link between bio-identical estrogen, progesterone, and breast

cancer. The Women's Health Initiative (WHI) study in 2003 raised concerns about "hormones

and breast cancer," but a long-term follow-up study published in JAMA in 2017 by one of the

original WHI authors found no increased mortality from breast cancer in the subjects over an 18-

year period. The number of patients receiving HRT 5 to 10 years after breast cancer treatment and remission

is increasing. However, hormone use in patients with a history of hormone-receptor-positive

tumors is not yet considered standard care. The decision to use hormones in this situation is an

informed one that the patient must make for herself.

Finally, patients with or recently recovered from breast cancer can receive testosterone alone to

help manage both AIS and menopausal symptoms.